Article
New approaches for defining sequence specific synthesis of heparan sulfate chains.
Advances in experimental medicine and biology - 1 Jan 1992
Rosenberg R D, de Agostini A I
Abstract excerpt
Mammalian cells synthesize heparan sulfate proteoglycans (HSPG) which consist of core proteins with covalently linked glycosaminoglycans (GAGs) of 50-150 disaccharide units. The GAGs exhibit great structural diversity which arise from differing arrangements of alternate disaccharide units. It has been hypothesized that HSPG may be involved in regulating the most basic aspects of cell biologic systems such as...
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