Article
The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse.
The Journal of biological chemistry - 21 Sept 2001
Merry C L, Bullock S L, Swan D C, Backen A C, Lyon M, Beddington R S, Wilson V A, Gallagher J T
Abstract excerpt
Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. We previously described the phenotype of mice with a gene-trap mutation in Hs2st, encoding the key HS 2-O-sulfotransferase enzyme in HS polymer modification. In contrast to the early developmental failure of embryos...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.