Article
The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo.
BMC developmental biology - 12 Nov 2008
Biellmann Franziska, Hülsmeier Andreas J, Zhou Dapeng, Cinelli Paolo, Hennet Thierry
Abstract excerpt
BACKGROUND: Glycosphingolipids (GSL) are integral components of mammalian cell membranes that are involved in cell adhesion and cell signaling processes. GSL are subdivided into structural series, like ganglio-, lacto/neolacto-, globo- and isoglo-series, which are defined by distinct trisaccharide cores. The beta1,3 N-acetylglucosaminyltransferase-V (B3gnt5) enzyme catalyzes the formation of the Lc3 structure,...
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