Article
Herpes simplex virus infection and propagation in a mouse L cell mutant lacking heparan sulfate proteoglycans.
Journal of virology - 1 Jan 1993
Gruenheid S, Gatzke L, Meadows H, Tufaro F
Abstract excerpt
We have isolated a variant line of mouse L cells, termed gro2C, which is partially resistant to infection by herpes simplex virus type 1 (HSV-1). Characterization of the genetic defect in gro2C cells revealed that this cell line harbors a specific defect in the heparan sulfate synthesis pathway....
Topics
- Adsorption
- Animals
- Biological Transport
- Chondroitin Sulfates
- Genetic Variation
- Glycosaminoglycans
- Heparan Sulfate Proteoglycans
- Heparin
- Heparitin Sulfate
- L Cells
- Mice
- Mutation
- Protein Processing, Post-Translational
- Proteoglycans
- Simplexvirus
- Viral Plaque Assay