Article
Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting converting activity that modifies an excess precursor pool.
The Journal of biological chemistry - 25 Oct 1996
Shworak N W, Fritze L M, Liu J, Butler L D, Rosenberg R D
Abstract excerpt
LTA cells synthesize a minor population of heparan sulfate proteoglycans (HSPGact) bearing anticoagulant heparan sulfate (HSact) with a specific monosaccharide sequence that accelerates the action of antithrombin (AT). LTA cells also synthesize a major population of heparan sulfate proteoglycans...
Topics
- Animals
- Anticoagulants
- Binding Sites
- Cell Line
- Cell-Free System
- Heparitin Sulfate
- Kinetics
- L Cells
- Mice
- Phenotype