Article
Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. III: Measurement of mutant frequency to 6-thioguanine resistance.
Mutagenesis - 1 Nov 1990
Sala-Trepat M, Cole J, Green M H, Rigaud O, Vilcoq J R, Moustacchi E
Abstract excerpt
The mutant frequencies (MF) at the HPRT locus of peripheral blood lymphocytes collected from breast cancer patients before and after treatment according to a defined protocol of the Institut Curie were compared to those from healthy donors. The treatment involved either a local radiotherapy (RT1)...
Topics
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Breast Neoplasms
- Cells, Cultured
- Combined Modality Therapy
- Cyclophosphamide
- Doxorubicin
- Drug Resistance
- Female
- Fluorouracil
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Middle Aged