Article
The use of cryopreserved lymphocytes in assessing inter-individual radiosensitivity with the micronucleus assay.
International journal of radiation biology - 1 Mar 2000
Burrill W, Levine E L, Hindocha P, Roberts S A, Scott D
Abstract excerpt
PURPOSE: The feasibility of using cryopreserved lymphocytes to detect inter-individual differences in chromosomal radiosensitivity was investigated. Typically, such studies are conducted with fresh blood samples but, in a clinical setting, when availability of samples is unpredictable, this is not always convenient. The sensitivity of 23 normal healthy donors, 11 breast cancer patients who had shown severe acute...
Topics
- Adult
- Aged
- Ataxia Telangiectasia
- Breast Neoplasms
- Cell Division
- Cryopreservation
- Dose-Response Relationship, Radiation
- Female
- Gamma Rays
- Genetic Variation
- Heterozygote
- Humans
- Lymphocytes
- Male
- Micronuclei, Chromosome-Defective