Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.

Carcinogenesis - 1 Feb 2011

Wang Hansong, Yamamoto Jennifer F, Caberto Christian, Saltzman Barbara, Decker Robert, Vogt Thomas M, Yokochi Lance, Chanock Stephen, Wilkens Lynne R, Le Marchand Loïc

Abstract excerpt

Animal work implicates chemical carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HAAs) as contributing to the development of colorectal cancer (CRC). The epidemiologic evidence, however, remains inconsistent possibly due to intra-individual variation in bioactivation of these compounds. We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amines
Share to Aryl Hydrocarbon Receptor Nuclear Translocator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Biotransformation

Share to Carcinogens

Share to Imidazoles

Share to Polycyclic Aromatic Hydrocarbons

Share to Quinoxalines

Source

Open in PubMed Open full text

Identifiers

PMID: 21081473
DOI: 10.1093/carcin/bgq237
PMCID: PMC3026844

Genes

ARNT
CYP1A2
AHR
CYP1A1
CYP1B1
NAT2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.PMID 21081473Read ↗

Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo.Semantic proximity Read ↗

The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.Semantic proximity Read ↗

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.Semantic proximity Read ↗

AHR gene expression and the polymorphism rs2066853 are associated with clinicopathological parameters in colorectal carcinoma.Semantic proximity Read ↗

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.Semantic proximity Read ↗

Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.Semantic proximity Read ↗

Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.Semantic proximity Read ↗

Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.Semantic proximity Read ↗

Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.Semantic proximity Read ↗

Cross-ancestry meta-analysis identifies a GSTP1 variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility.Semantic proximity Read ↗

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.Semantic proximity Read ↗

Interplay between heterocyclic amines in cooked meat and metabolic phenotype in the etiology of colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.