Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.

Pharmacogenetics - 1 Mar 2002

Ishibe Naoko, Sinha Rashmi, Hein David W, Kulldorff Martin, Strickland Paul, Fretland Adrian J, Chow Wong-Ho, Kadlubar Fred F, Lang Nicholas P, Rothman Nathaniel

Abstract excerpt

High red meat intake has been linked with an increased risk of colorectal cancer and adenomas. During high temperature cooking of red meats, heterocyclic amines (HCAs) are generated; however, to be carcinogenic, they must be metabolized by enzymes including cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 (NAT1) and/or N-acetyltransferase 2 (NAT2). We have conducted a clinic-based case-control study of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cooking

Share to Cytochrome P-450 CYP1A2

Share to Heterocyclic Compounds

Share to Quinolines

Source

Identifiers

PMID: 11875368
DOI: 10.1097/00008571-200203000-00008

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.PMID 11875368Read ↗

Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.Semantic proximity Read ↗

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.Semantic proximity Read ↗

Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo.Semantic proximity Read ↗

Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.Semantic proximity Read ↗

Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.Semantic proximity Read ↗

Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a Dutch population.Semantic proximity Read ↗

Effects of phenotypes in heterocyclic aromatic amine (HCA) metabolism-related genes on the association of HCA intake with the risk of colorectal adenomas.Semantic proximity Read ↗

Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.Semantic proximity Read ↗

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.Semantic proximity Read ↗

Meat, metabolic genotypes and risk for colorectal cancer.Semantic proximity Read ↗

A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.Semantic proximity Read ↗

Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.