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Article

Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii.

Mutation research - 30 Sept 2002

Le Marchand Loïc, Hankin Jean H, Pierce Lisa M, Sinha Rashmi, Nerurkar Pratibha V, Franke Adrian A, Wilkens Lynne R, Kolonel Laurence N, Donlon Timothy, Seifried Ann, Custer Laurie J, Lum-Jones Annette, Chang Wendy

Abstract excerpt

Heterocyclic amines (HAAs) and polycyclic hydrocarbons are suspected colorectal cancer (CRC) carcinogens that are found in well-done meat. They require metabolic activation by phase I enzymes, such as the smoking-inducible CYP1A isoenzymes. N-acetyltransferase 2 (NAT2) also play a role in the further activation of HAAs. We conducted a population-based case-control study in Hawaii to test the associations of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12351160
DOI: 10.1016/s0027-5107(02)00167-7

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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