Article
Evolutionary pathways in BRCA1-associated breast tumors.
Cancer discovery - 1 Jun 2012
Martins Filipe C, De Subhajyoti, Almendro Vanessa, Gönen Mithat, Park So Yeon, Blum Joanne L, Herlihy William, Ethington Gabrielle, Schnitt Stuart J, Tung Nadine, Garber Judy E, Fetten Katharina, Michor Franziska, Polyak Kornelia
Abstract excerpt
BRCA1-associated breast tumors display loss of BRCA1 and frequent somatic mutations of PTEN and TP53. Here we describe the analysis of BRCA1, PTEN, and p53 at the single cell level in 55 BRCA1-associated breast tumors and computational methods to predict the relative temporal order of somatic events, on the basis of the frequency of cells with single or combined alterations. Although there is no obligatory order...
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