Article
The life history of 21 breast cancers.
Cell - 25 May 2012
Nik-Zainal Serena, Van Loo Peter, Wedge David C, Alexandrov Ludmil B, Greenman Christopher D, Lau King Wai, Raine Keiran, Jones David, Marshall John, Ramakrishna Manasa, Shlien Adam, Cooke Susanna L, Hinton Jonathan, Menzies Andrew, Stebbings Lucy A, Leroy Catherine, Jia Mingming, Rance Richard, Mudie Laura J, Gamble Stephen J, Stephens Philip J, McLaren Stuart, Tarpey Patrick S, Papaemmanuil Elli, Davies Helen R, Varela Ignacio, McBride David J, Bignell Graham R, Leung Kenric, Butler Adam P, Teague Jon W, Martin Sancha, Jönsson Goran, Mariani Odette, Boyault Sandrine, Miron Penelope, Fatima Aquila, Langerød Anita, Aparicio Samuel A J R, Tutt Andrew, Sieuwerts Anieta M, Borg Åke, Thomas Gilles, Salomon Anne Vincent, Richardson Andrea L, Børresen-Dale Anne-Lise, Futreal P Andrew, Stratton Michael R, Campbell Peter J
Abstract excerpt
Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a cancer's...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.