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Article

Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.

Nature genetics - 1 Jan 2017

Lo Min-Tzu, Hinds David A, Tung Joyce Y, Franz Carol, Fan Chun-Chieh, Wang Yunpeng, Smeland Olav B, Schork Andrew, Holland Dominic, Kauppi Karolina, Sanyal Nilotpal, Escott-Price Valentina, Smith Daniel J, O'Donovan Michael, Stefansson Hreinn, Bjornsdottir Gyda, Thorgeirsson Thorgeir E, Stefansson Kari, McEvoy Linda K, Dale Anders M, Andreassen Ole A, Chen Chi-Hua

Abstract excerpt

Personality is influenced by genetic and environmental factors and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci, significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132-260,861). Of these genome-wide significant loci, extraversion was associated...

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Identifiers

PMID: 27918536
DOI: 10.1038/ng.3736
PMCID: PMC5278898

Genes

PCDH15
WSCD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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