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Article

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses.

Journal of controlled release : official journal of the Controlled Release Society - 28 Dec 2012

Bradshaw Angela C, Coughlan Lynda, Miller Ashley M, Alba Raul, van Rooijen Nico, Nicklin Stuart A, Baker Andrew H

Abstract excerpt

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions is mediated by a high-affinity interaction between the capsid hexon protein and blood coagulation factor X (FX),...

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Source

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Identifiers

PMID: 22626939
DOI: 10.1016/j.jconrel.2012.05.025
PMCID: PMC3520007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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