Article
Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo.
PLoS pathogens - 1 Feb 2015
Ma Jiangtao, Duffy Margaret R, Deng Lin, Dakin Rachel S, Uil Taco, Custers Jerome, Kelly Sharon M, McVey John H, Nicklin Stuart A, Baker Andrew H
Abstract excerpt
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX) interacts directly with the adenovirus type 5 (Ad5) hexon. FX can act as a bridge to bind heparan sulphate proteoglycans, leading to substantial Ad5 hepatocyte...
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