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Article

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

20 Jun 2011

Abstract excerpt

Adenovirus is a robust vector for therapeutic applications, but its use is limited by our understanding of its complex in vivo pharmacology. In this review we describe the necessity of identifying its natural, widespread, and multifaceted interactions with the host since this information will be crucial for efficiently redirecting virus into target cells. In the rational design of vectors, the notion of...

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PMID: 21453281
DOI: 10.2174/156652311796150363

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