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Binding of adenovirus species C hexon to prothrombin and the influence of hexon on vector properties in vitro and in vivo

26 Sept 2022

Abstract excerpt

The majority of adenovirus (Ad) vectors are based on human Ad type 5, which is a member of Ad species C. Species C also includes the closely-related types 1, 2, 6, 57 and 89. It is known that coagulation factors bind to Ad5 hexon and play a key role in the liver tropism of Ad5 vectors, but it is unclear how coagulation factors affect vectors derived from other species C Ads. We evaluated species C Ad vectors both...

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PMID: 36156097
DOI: 10.1371/journal.ppat.1010859

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