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Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs

19 Oct 2015

Abstract excerpt

Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been extensively studied in preclinical models and clinical trials over the past two decades. However, the thorough understanding of the HAdV-5 interaction with human subjects has uncovered major concerns about its product applicability. High vector-associated toxicity and widespread preexisting immunity have been shown to significantly impede...

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PMID: 26478249
DOI: 10.1038/mt.2015.194

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