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Article

Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer

19 Apr 2011

Abstract excerpt

As much as 90% of an intravenously (i.v.) injected dose of adenovirus serotype 5 (Ad5) is absorbed and destroyed by liver Kupffer cells. Viruses that escape these cells can then transduce hepatocytes after binding factor X (FX). Given that interactions with FX and Kupffer cells are thought to occur on the Ad5 hexon protein, we replaced its exposed hypervariable regions (HVR) with those from Ad6. When tested in...

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Identifiers

PMID: 21505422
DOI: 10.1038/mt.2011.71

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