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Article

Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome.

PLoS genetics - 1 Mar 2018

Sinha Anurag Kumar, Possoz Christophe, Durand Adeline, Desfontaines Jean-Michel, Barre François-Xavier, Leach David R F, Michel Bénédicte

Abstract excerpt

It was recently reported that the recBC mutants of Escherichia coli, deficient for DNA double-strand break (DSB) repair, have a decreased copy number of their terminus region. We previously showed that this deficit resulted from DNA loss after post-replicative breakage of one of the two sister-chromosome termini at cell division. A viable cell and a dead cell devoid of terminus region were thus produced and,...

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Source

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Identifiers

PMID: 29522563
DOI: 10.1371/journal.pgen.1007256
PMCID: PMC5862497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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