Article
Pax3( GFP ) , a new reporter for the melanocyte lineage, highlights novel aspects of PAX3 expression in the skin.
Pigment cell & melanoma research - 1 Sept 2012
Djian-Zaouche Johanna, Campagne Cécile, Reyes-Gomez Edouard, Gadin-Czerw Stéphanie, Bernex Florence, Louise Anne, Relaix Frédéric, Buckingham Margaret, Panthier Jean-Jacques, Aubin-Houzelstein Geneviève
Abstract excerpt
The paired box gene 3 (Pax3) is expressed during pigment cell development. We tested whether the targeted allele Pax3(GFP) can be used as a reporter gene for pigment cells in the mouse. We found that enhanced green fluorescent protein (GFP) can be seen readily in every melanoblast and melanocyte in the epidermis and hair follicles of Pax3(GFP/+) heterozygotes. The GFP was detected at all differentiation stages,...
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