Article
Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a-/- mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele.
Melanoma research - 1 Feb 2016
Campagne Cécile, Reyes-Gomez Edouard, Loiodice Sophia, Gadin Stéphanie, Ezagal Jacky, Bernex Florence, Abitbol Marie, Louise Anne, Beermann Friedrich, Panthier Jean-Jacques, Aubin-Houzelstein Geneviève, Egidy Giorgia
Abstract excerpt
The role of the Pax3 gene in embryonic development of pigment cells is well characterized. By contrast, the function of Pax3 in melanoma development is controversial. Indeed, data obtained from cultured cells suggest that PAX3 may contribute to melanomagenesis. PAX3 is found to be overexpressed in melanomas and also in nevi compared with normal skin samples. Pax3 homozygous loss of function is embryonic lethal....
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Cell Separation
- Cell Transformation, Neoplastic
- Cells, Cultured
- Female
- Genes, Reporter
- Genes, p16