Article
Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.
Development (Cambridge, England) - 1 Jan 2007
Kurek Dorota, Garinis George A, van Doorninck J Hikke, van der Wees Jacqueline, Grosveld Frank G
Abstract excerpt
The transcription factor Gata3 is crucially involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, what pathways are involved and how Gata3 differentially regulates distinct cell populations within the hair follicle. Here, we describe a conditional Gata3-/- mouse (K14-Gata3-/-) in which Gata3 is specifically deleted in...
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