Article

Pax3 deficiency diminishes melanocytes in the developing mouse cochlea

2023-06-09

Abstract excerpt

Cochlear melanocytes are intermediate cells in the stria vascularis that generate endocochlear potentials required for auditory function. Human PAX3 mutations cause Waardenburg syndrome and abnormalities of melanocytes, manifested as congenital hearing loss and hypopigmentation of skin, hair and eyes. However, the underlying mechanism of hearing loss remains unclear. During development, cochlear melanocytes in the...

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Literature Corpus work: 22fdb23b-4390-54b9-b2c3-c724877dce5c
DOI: 10.21203/rs.3.rs-2990436/v1

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