Article
The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling.
Diabetes - 1 Sept 2012
Thameem Farook, Puppala Sobha, Schneider Jennifer, Bhandari Basant, Arya Rector, Arar Nedal H, Vasylyeva Tetyana L, Farook Vidya S, Fowler Sharon, Almasy Laura, Blangero John, Duggirala Ravindranath, Abboud Hanna E
Abstract excerpt
The objective of this study is to identify and characterize the genetic variants related to the glomerular filtration rate (GFR) linkage on 2q37. Of the positional candidate genes, we selected IRS1 and resequenced its 2-kb promoter region and exons for sequence variants in 32 subjects. A total of 11 single nucleotide polymorphisms (SNPs) were identified. To comprehensively cover the 59-kb-long intron-1, eight...
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