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Article

The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.

The Journal of clinical endocrinology and metabolism - 1 May 2000

Hribal M L, Federici M, Porzio O, Lauro D, Borboni P, Accili D, Lauro R, Sesti G

Abstract excerpt

Molecular scanning of insulin receptor substrate-1 (IRS-1) revealed several amino acid substitutions. The most common IRS-1 variant, a Gly to Arg972 change, is more prevalent among type 2 diabetic patients. In this study we overexpressed wild-type and Arg972IRS-1 variant in L6 skeletal muscle cells and examined the functional consequences of this polymorphism on insulin metabolic signaling. L6 cells expressing...

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Share to Glucose Transporter Type 1
Share to Glucose Transporter Type 4

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycine

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Share to Monosaccharide Transport Proteins

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Source

Identifiers

PMID: 10843189
DOI: 10.1210/jcem.85.5.6608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.PMID 10843189Read ↗

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Metabolic risk markers in an overweight and normal weight population with oversampling of carriers of the IRS-1 972Arg-variant.Semantic proximity Read ↗

Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistanceSemantic proximity Read ↗

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Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

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