Article
The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 2013
De Cosmo Salvatore, Prudente Sabrina, Lamacchia Olga, Pucci Laura, Lucchesi Daniela, Mendonca Christine, Bailetti Diego, Copetti Massimiliano, Pellegrini Fabio, Cignarelli Mauro, Penno Giuseppe, Doria Alessandro, Trischitta Vincenzo
Abstract excerpt
BACKGROUND: In Mexican Americans, the IRS1 G972R polymorphism (rs1801278) has been associated to such a marked reduction in glomerular filtration rate (GFR) (i.e. β = -8.3 mL/min/1.73 m(2)) to be considered a major determinant of kidney function. METHODS: This was a cross-sectional study to investigate whether a similarly strong effect can also be observed among individuals of European ancestry. We investigated a...
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