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IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance

1 Sept 2018

Abstract excerpt

BACKGROUND: Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling. Several polymorphisms in the IRS genes have been identified, but only the Gly to Arg 972 substitution of IRS-1 seems to have a pathogenic role in the development of type 2 diabetes mellitus (T2DM). Many polymorphisms described in IRS-1 gene, especially Gly972Arg substitution, are shown to be associated with insulin...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 30319284
DOI: 10.2147/tacg.s171096

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