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Article

The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.

The Journal of clinical endocrinology and metabolism - 1 Jul 2003

Marini Maria Adelaide, Frontoni Simona, Mineo Davide, Bracaglia Daniela, Cardellini Marina, De Nicolais Pierluigi, Baroni Alessandra, D'Alfonso Rossella, Perna Michela, Lauro Davide, Federici Massimo, Gambardella Sergio, Lauro Renato, Sesti Giorgio

Abstract excerpt

The insulin receptor substrate-1 (IRS-1) gene has been considered a candidate for insulin resistance, type 2 diabetes, and coronary artery disease. To investigate the relationship between the common Gly(972)Arg IRS-1 variant and the presence of cardiovascular risk factors, 153 glucose-tolerant, unrelated offspring of type 2 diabetic patients were studied. There were no differences between Arg(972) IRS-1 carriers...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12843189
DOI: 10.1210/jc.2002-021716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.PMID 12843189Read ↗

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