Article

Impact of Aging, Sex, and Species on the mRNA Expression of Matrix Metalloproteinases Following Ischemic Stroke

2026-02-26

Abstract excerpt

Matrix metalloproteinase (MMP) expression and function are highly context dependent, varying across physiological and pathological conditions. We previously documented the expression profiles of select MMPs in the ischemic brains of young male rodents. However, aging is a major risk factor for stroke in humans and is associated with vasculature alterations, increased oxidative stress, and elevated inflammation. In...

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Literature Corpus work: 5efcc789-bf71-5e1a-80a1-01decacb0336
DOI: 10.64898/2026.02.24.707225

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