Article
The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2012
Pei Yu, Smith Alicia K, Wang Yongjun, Pan Yanli, Yang Jian, Chen Qi, Pan Weigang, Bao Feng, Zhao Lisha, Tie Changle, Wang Yizheng, Wang Jian, Zhen Wenfeng, Zhou Jinxia, Ma Xin
Abstract excerpt
Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. A...
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