Article
Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.
Molecular psychiatry - 1 Mar 2010
Verhagen M, van der Meij A, van Deurzen P A M, Janzing J G E, Arias-Vásquez A, Buitelaar J K, Franke B
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-like effects in animals and may be implicated in the etiology of mood-related phenotypes. However, genetic association studies of the BDNF Val66Met polymorphism (single nucleotide polymorphism rs6265) in major depressive disorder (MDD) have produced inconsistent results. We conducted a meta-analysis of studies comparing the...
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