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Article

Val66Met polymorphism in the BDNF gene and antidepressant response in depression: an updated meta-analysis.

Personalized medicine - 1 Dec 2025

Tiongco Raphael Enrique, Arbas Roselle, Caguiat Ana, Castro Eliezer John, Dela Cruz Kristin Chernelle, Dominguez Michael John, Guintu Ma Agatha Anne, Mercado Julie Ann, Vallo Johana

Abstract excerpt

INTRODUCTION: The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been linked to antidepressant treatment response in patients with major depressive disorder (MDD), yet findings remain inconclusive. This updated meta-analysis aimed to clarify this association and explore subgroup effects based on antidepressant class and treatment duration. METHODS: A systematic search of PubMed,...

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Alleles
Antidepressive Agents
Brain-Derived Neurotrophic Factor
East Asian People
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Depressive Disorder

Polymorphism, Single Nucleotide

Selective Serotonin Reuptake Inhibitors

Source

Identifiers

PMID: 40772427
DOI: 10.1080/17410541.2025.2544352

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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