BDNF Val66Met Variant as a Genetic Risk Factor for Major Depressive Disorder in Saudis.

doi:10.1177/19450265261419292

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BDNF Val66Met Variant as a Genetic Risk Factor for Major Depressive Disorder in Saudis.

Genetic testing and molecular biomarkers - 1 Feb 2026

Binmahfouz Lenah S, Alkhaldi Muteb F, Qutub Yasmeen A, Albeladi Sara A, Alzahrani Alzahraa A, Eid Basma G, Bagher Amina M

Abstract excerpt

OBJECTIVE: Major depressive disorder (MDD) is a prevalent and disabling psychiatric condition in Saudi Arabia, with genetic susceptibility remaining incompletely characterized. Reduced brain-derived neurotrophic factor (BDNF) activity has been implicated in MDD. The Val66Met polymorphism (rs6265), involving the substitution of valine (Val, G allele) with methionine (Met, A allele), impairs activity-dependent BDNF...

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PMID: 41631468
DOI: 10.1177/19450265261419292

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