Article
N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk.
Pharmacogenetics - 1 Apr 2002
Wikman Harriet, Piirilä Päivi, Rosenberg Christina, Luukkonen Ritva, Kääriä Katja, Nordman Henrik, Norppa Hannu, Vainio Harri, Hirvonen Ari
Abstract excerpt
We observed previously that polymorphisms in glutathione S-transferase (GST) genes modified allergic responses to diisocyanate exposure. Here, we extended the study to examine the possible role of N-acetyltransferase (NAT) genotypes in the development of diisocyanate-induced ill effects, both separately and in combination with the previously examined GSTM1, GSTM3, GSTP1 and GSTT1 genotypes. The study population...
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