Article
Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure.
Pharmacogenetics - 1 Jul 2001
Piirilä P, Wikman H, Luukkonen R, Kääriä K, Rosenberg C, Nordman H, Norppa H, Vainio H, Hirvonen A
Abstract excerpt
Diisocyanates are the most common low molecular weight chemicals to cause occupational asthma. However, only some 5-10% of exposed workers develop asthma, which suggests an underlying genetic susceptibility. Diisocyanates and their metabolites may be conjugated with glutathione by glutathione S-transferases (GSTs). We examined whether polymorphisms in the GSTM1, GSTM3, GSTP1 and GSTT1 genes modify allergic...
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