Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters.

Nature biotechnology - 20 May 2012

Sharon Eilon, Kalma Yael, Sharp Ayala, Raveh-Sadka Tali, Levo Michal, Zeevi Danny, Keren Leeat, Yakhini Zohar, Weinberger Adina, Segal Eran

Abstract excerpt

Despite extensive research, our understanding of the rules according to which cis-regulatory sequences are converted into gene expression is limited. We devised a method for obtaining parallel, highly accurate gene expression measurements from thousands of designed promoters and applied it to measure the effect of systematic changes in the location, number, orientation, affinity and organization of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Genetic Engineering

Share to Genome, Fungal

Share to Nucleosomes

Share to Research Design

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 22609971
DOI: 10.1038/nbt.2205
PMCID: PMC3374032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters.PMID 22609971Read ↗

Massively parallel synthetic promoter assays reveal the in vivo effects of binding site variants.Semantic proximity Read ↗

Meta-analysis of massive parallel reporter assays enables functional regulatory elements predictionSemantic proximity Read ↗

Massively parallel reporter assay reveals promoter-, position-, and strand-specific effects in transcription start sitesSemantic proximity Read ↗

Billion-Scale Deciphering of Human Gene Regulatory GrammarSemantic proximity Read ↗

Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross.Semantic proximity Read ↗

A Precise Genome Editing Method Reveals Insights into the Activity of Eukaryotic Promoters.Semantic proximity Read ↗

Promoter sequence and architecture determine expression variability and confer robustness to genetic variants.Semantic proximity Read ↗

Promoter sequence and architecture determine expression variability and confer robustness to genetic variantsSemantic proximity Read ↗

The emergence and evolution of gene expression in genome regions replete with regulatory motifs.Semantic proximity Read ↗

Systematic evaluation of the impact of promoter proximal short tandem repeats on expressionSemantic proximity Read ↗

Multi-landmark alignment of genomic signals reveals conserved expression patterns across transcription start sitesSemantic proximity Read ↗

High-throughput functional analysis of IncRNA core promoters elucidatesrules governing tissue-specificitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.