Article

Systematic evaluation of the impact of promoter proximal short tandem repeats on expression

2025-09-17

Abstract excerpt

Genetic variation at thousands of short tandem repeats (STRs), which consist of consecutive repeated sequences of 1-6bp, has been statistically associated with gene expression and other molecular phenotypes in humans. However, the causality and regulatory mechanisms for most of these STRs remains unknown. Massively parallel reporter assays (MPRA) enable testing the regulatory activity of a large number of synthesi...

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Literature Corpus work: 8ae552ca-a49a-5b6a-9be8-27284cf61056
DOI: 10.1101/2025.09.14.676153

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