Article
Application of the F(ST) statistics to explore pharmacogenomic diversity in the Brazilian population.
Pharmacogenomics - 1 May 2012
Suarez-Kurtz Guilherme, Pena Sergio D J, Hutz Mara H
Abstract excerpt
BACKGROUND: New drug applications submitted to regulatory agencies in developing countries rarely include data from local clinical trials. We used the F(ST) statistics to explore the pharmacogenomic diversity of the Brazilian population and its potential implications in drug regulatory assessment and decisions. METHODS: The F(ST) analyses were based on data for 44 polymorphisms in 12 pharmacogenes among 1034...
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