Article
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians.
The pharmacogenomics journal - 1 Jun 2012
Suarez-Kurtz G, Genro J P, de Moraes M O, Ojopi E B, Pena S D J, Perini J A, Ribeiro-dos-Santos A, Romano-Silva M A, Santana I, Struchiner C J
Abstract excerpt
The impact of biogeographical ancestry, self-reported 'race/color' and geographical origin on the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8*2, *3, *4, CYP2C9*2, *3, *5, *11, CYP2C19*2, *3 and *17) and their haplotypes was assessed in a representative cohort of the Brazilian population (n=1034). TaqMan assays were used for allele discrimination at each CYP2C locus investigated. Individual...
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