Article
Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.
Nature - 13 Feb 1992
Kelly A, Powis S H, Kerr L A, Mockridge I, Elliott T, Bastin J, Uchanska-Ziegler B, Ziegler A, Trowsdale J, Townsend A
Abstract excerpt
Presentation of cytoplasmic antigens to class I-restricted cytotoxic T cells implied the existence of a specialized peptide transporter. For most class I heavy chains, association with peptides of the appropriate length is required for stable assembly with beta 2-microglobulin. Mutant cells RMA-S...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Electrophoresis, Polyacrylamide Gel
- Gene Expression
- Genotype
- Histocompatibility Antigens Class I
- Humans
- Major Histocompatibility Complex
- Membrane Proteins