Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression.

Molecular immunology - 1 Feb 2006

Long Alyssa B, Ferguson Angela M, Majumder Parimal, Nagarajan Uma M, Boss Jeremy M

Abstract excerpt

RFXAP is required for the transcriptional regulation of MHC-II genes. Mutations in RFXAP are the genetic basis for complementation group D cases of the bare lymphocyte syndrome (BLS) immunodeficiency. Comparative genomic sequence analysis was conducted and found that only the C-terminal half of the protein is conserved among vertebrates. The C-terminal third of RFXAP, which contained an extensive glutamine-rich...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Burkitt Lymphoma
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, MHC Class II

Share to HLA-DP Antigens

Share to Protein Interaction Mapping

Share to Regulatory Sequences, Nucleic Acid

Share to Severe Combined Immunodeficiency

Share to Vertebrates

Source

Identifiers

PMID: 16337482
DOI: 10.1016/j.molimm.2005.03.008

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression.PMID 16337482Read ↗

The Bare Lymphocyte Syndrome and the Regulation of MHC ExpressionSemantic proximity Read ↗

Type III bare lymphocyte syndrome associated with a novel RFXAP mutation: a case report.Semantic proximity Read ↗

Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex.Semantic proximity Read ↗

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

When the lymphocyte loses its clothes.Semantic proximity Read ↗

Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.Semantic proximity Read ↗

Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complexSemantic proximity Read ↗

Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency.Semantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A.Semantic proximity Read ↗

Analysis of the defect in IFN-gamma induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor.Semantic proximity Read ↗

Discoordinate expression of invariant chain and MHC class II genes in class II transactivator-transfected fibroblasts defective for RFX5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.