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Article

Immunohistochemical Detection of the BRAF V600E-mutated Protein in Papillary Thyroid Carcinoma

24 Feb 2012

Abstract excerpt

The V600E mutation of the B-type Raf kinase (BRAF) gene is a common event in papillary thyroid carcinoma (PTC) and seems to play a key role in the development and progression of this disease. We evaluated the expression of the mutated BRAF V600E protein in 144 cases of PTC using a novel mutation-specific antibody. Seventy-six PTCs (52.8%) showed unequivocal diffuse cytoplasmic expression of the mutated BRAF...

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PMID: 22592144
DOI: 10.1097/pas.0b013e318246b527

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Immunohistochemical Detection of the BRAF V600E-mutated Protein in Papillary Thyroid CarcinomaPMID 22592144Read ↗

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