Article
BRAF mutations are associated with some histological types of papillary thyroid carcinoma.
The Journal of pathology - 1 Feb 2004
Trovisco Vítor, Vieira de Castro Inês, Soares Paula, Máximo Valdemar, Silva Paula, Magalhães João, Abrosimov Alexander, Guiu Xavier Matias, Sobrinho-Simões Manuel
Abstract excerpt
Mutations in the BRAF gene have recently been detected in a wide range of neoplastic lesions with a particularly high prevalence in melanoma and papillary thyroid carcinoma (PTC). The hot-spot mutation BRAF(V599E) is frequently detected in PTC (36-69%), in contrast to its absence in other benign or malignant thyroid lesions. In order to unravel whether there is any association between the occurrence of the BRAF...
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