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Article

BRAF mutations are associated with some histological types of papillary thyroid carcinoma.

The Journal of pathology - 1 Feb 2004

Trovisco Vítor, Vieira de Castro Inês, Soares Paula, Máximo Valdemar, Silva Paula, Magalhães João, Abrosimov Alexander, Guiu Xavier Matias, Sobrinho-Simões Manuel

Abstract excerpt

Mutations in the BRAF gene have recently been detected in a wide range of neoplastic lesions with a particularly high prevalence in melanoma and papillary thyroid carcinoma (PTC). The hot-spot mutation BRAF(V599E) is frequently detected in PTC (36-69%), in contrast to its absence in other benign...

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Share to Carcinoma, Papillary
Share to Carcinoma, Papillary, Follicular
Share to Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Proteins B-raf

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Share to Thyroid Neoplasms

Source

Identifiers

PMID: 14743508
DOI: 10.1002/path.1511

Genes

BRAF
HTT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14743508-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

BRAF mutations are associated with some histological types of papillary thyroid carcinoma.PMID 14743508Read ↗

Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness.Semantic proximity Read ↗

BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma.Semantic proximity Read ↗

Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights.Semantic proximity Read ↗

Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF status.Semantic proximity Read ↗

Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center.Semantic proximity Read ↗

BRAF V600E mutation in papillary thyroid carcinoma: significant association with node metastases and extra thyroidal invasion.Semantic proximity Read ↗

Papillary Thyroid Carcinoma With Rare Exon 15 BRAF Mutation Has Indolent Behavior: A Single-Institution ExperienceSemantic proximity Read ↗

Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant.Semantic proximity Read ↗

Papillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinctSemantic proximity Read ↗

Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression.Semantic proximity Read ↗

Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation.Semantic proximity Read ↗

BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas.Semantic proximity Read ↗

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