Article
Utilization of a MAB for BRAF(V600E) detection in papillary thyroid carcinoma.
Endocrine-related cancer - 1 Dec 2012
Bullock M, O'Neill C, Chou A, Clarkson A, Dodds T, Toon C, Sywak M, Sidhu S B, Delbridge L W, Robinson B G, Learoyd D L, Capper D, von Deimling A, Clifton-Bligh R J, Gill A J
Abstract excerpt
Identification of BRAF(V600E) in thyroid neoplasia may be useful because it is specific for malignancy, connotes a worse prognosis, and is the target of novel therapies currently under investigation. Sanger sequencing is the 'gold standard' for mutation detection but is subject to sampling error and requires resources beyond many diagnostic pathology laboratories. In this study, we compared immunohistochemistry...
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