Article
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness.
Virchows Archiv : an international journal of pathology - 1 Jun 2005
Trovisco Vítor, Soares Paula, Preto Ana, de Castro Inês Vieira, Lima Jorge, Castro Patrícia, Máximo Valdemar, Botelho Tiago, Moreira Severina, Meireles Ana Margarida, Magalhães João, Abrosimov Alexander, Cameselle-Teijeiro José, Sobrinho-Simões Manuel
Abstract excerpt
A high prevalence of the BRAF(V600E) somatic mutation was recently reported in several series of papillary thyroid carcinomas (PTC). This mutation appears to be particularly prevalent in PTC with a predominantly papillary architecture. Another BRAF mutation (K601E) was detected in a follicular adenoma and in some cases of the follicular variant of PTC. The few studies on record provided controversial data on the...
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