Article
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant.
Human molecular genetics - 1 May 2001
Chadwick B P, Willard H F
Abstract excerpt
MacroH2A1 is an unusual variant of the core histone H2A which is enriched in chromatin on the inactive X chromosome of female mammals. The N-terminal third of the protein shares 65% amino acid identity with core histone H2A, while the remaining two-thirds of the protein are novel, with a small stretch of basic amino acids and a putative leucine zipper motif. We have now cloned a second macroH2A gene, encoding...
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