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Article

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.

European journal of human genetics : EJHG - 1 Feb 2013

Flachsbart Friederike, Möller Michael, Däumer Carolin, Gentschew Liljana, Kleindorp Rabea, Krawczak Michael, Caliebe Amke, Schreiber Stefan, Nebel Almut

Abstract excerpt

Our study demonstrates that the genetic investigation of forkhead box O3A gene (FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene. If unaccounted for, this high degree of homology can cause serious genotyping or sequencing errors. Here, we present an experimental set-up that allows reliable data generation for...

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Share to Forkhead Box Protein O3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22588664
DOI: 10.1038/ejhg.2012.83
PMCID: PMC3548564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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