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Article

FOXO3 gene variants and human aging: coding variants may not be key players.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2012

Donlon Timothy A, Curb J David, He Qimei, Grove John S, Masaki Kamal H, Rodriguez Beatriz, Elliott Ayako, Willcox D Craig, Willcox Bradley J

Abstract excerpt

FOXO3 is generally recognized as a "master" gene in aging since its association with longevity has been replicated in multiple organisms and human populations. A group of single nucleotide polymorphisms in linkage disequilibrium with a coding region has been associated with human longevity, but t...

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Identifiers

PMID: 22459618
DOI: 10.1093/gerona/gls067
PMCID: PMC3668389

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22459618-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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