Article
The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer.
Nucleic acids research - 20 Jun 2018
Grossi Valentina, Forte Giovanna, Sanese Paola, Peserico Alessia, Tezil Tugsan, Lepore Signorile Martina, Fasano Candida, Lovaglio Rosaura, Bagnulo Rosanna, Loconte Daria C, Susca Francesco C, Resta Nicoletta, Simone Cristiano
Abstract excerpt
The HSF and FOXO families of transcription factors play evolutionarily conserved roles in stress resistance and lifespan. In humans, the rs2802292 G-allele at FOXO3 locus has been associated with longevity in all human populations tested; moreover, its copy number correlated with reduced frequency of age-related diseases in centenarians. At the molecular level, the intronic rs2802292 G-allele correlated with...
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